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In analyzing the costs and bene ts of technological advances for the treatment of heart attacks, low-birth-weight infants, depression, and cataracts, the bene ts of the technological changes exceeded their costs For a fth condition, breast cancer, bene ts and costs were about the same The authors conclude that, in general, technological improvements in medical care are worth the associated increase in cost when improvements in medical care, survival, and quality of life are considered It seems plausible to extend this same logic to pharmacogenomics-based drug therapies An additional cost that must be considered for pharmacogenomicsbased drugs is testing cost To optimize or tailor drug therapy to individuals, each person must be genotyped Traditionally, lab test costs have been paid by the individual or some third party (eg, insurers or governments).

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In the case of genotyping for the purpose of speci c drug use, testing costs may be bundled with the drug as part of its market price Most likely, pharmaceutical companies will market their drugs with genetic tests for response and safety There will also be a derived demand for the services of genetic counselors to help patients and prescribers interpret and act on test results..

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Apart from high speeds for individual users and a high overall capacity of a cell, cell size is another important factor that decides if an 802.16 network can be operated economically. Ideally, a single cell should be as large as possible and should have a very high capacity in order to serve many users simultaneously. However, these goals are mutually exclusive. The larger the area covered by a cell, the more difficult it is to serve remote subscribers. As a consequence, distant subscribers have to be served with a lower modulation and higher coding scheme, which reduces the overall capacity of a cell. A cell serving only users in close proximity can have a much higher capacity, as less time has to be spent sending data packets with lower modulation schemes, which requires more time then sending data packets of the same size with 16- or 64-QAM modulation. In urban and suburban areas, cell sizes will be small because the number of users per square kilometer is high. In rural areas on the other hand, cell sizes need to be much larger in order to cover enough subscribers to make the operation of the network economically feasible. However, the capacity of the cell is reduced as the percentage of subscribers, which are quite distant from the cell, is higher than for the rural scenario. Also, the achievable data rates per user will be lower, especially for more distant subscribers. See Figure 5.3. WiMAX is a wireless technology, but will mostly be used with stationary terminals until the introduction of the 802.16e extension of the standard, which adds mobility for terminals. Reception conditions can be substantially increased by installing an outdoor directional antenna on the roof of a building, pointing towards the base station. Users with no other

Why Use cases illustrate how the requirements are applied to achieve goals described in the Vision and Scope document. As mentioned previously, use cases are a critical foundation for effective application design and construction. They are also an essential prerequisite for developing test cases that objectively verify whether the software meets expectations. Who As in other requirements best practices, the project manager is responsible for this task, but the entire team (including the architect, development team members, and testing team members) is involved in the process to ensure that they have a thorough understanding of the requirements. It is critical to create a feedback loop with customers during the creation of use cases, since it is likely that requirements will change as the project proceeds. By interacting with a group of customers who represent actual or potential application end users, the team can begin to separate information that is useful to the application from extraneous information. The stakeholders feedback is also important for determining if enough use cases have been made, or if more need to be created. How Every requirement should have two types of use cases: positive and negative. Positive use cases describe the feature s expected usage. They are

Best practices for code construction Source code Test cases Policy for the use of the source control system Policy for the use of the automated build system

Figure 7.3 In the FDC approach the cost of input factors are assigned to services. For example, service 1 is assigned 0:8 of the cost factors in the rst cost pool and 0:4 of the cost factors in the second cost pool. The different common cost pools and the coef cients for sharing the cost of the common factors are de ned by the designer of the system.

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