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During his years of full-time research at Harvard, he solved the problem of the cochlea, for which he received the Nobel Prize in 1961 In 1964, he accepted a professorship at the University of Hawaii, where he remained until his death By careful microscopic study of the cochlea, B k sy determined the actual movements of the basilar membrane in response to tones (see B k sy, 1947) When William James Hall was built at Harvard to house the psychology department, a special oating room was constructed in the basement for B k sy s experiments The entire room oated on an air cushion generated by a large air compressor Furthermore, the experimental table oated within the oating room on its own compressor For B k sy s experiments it was necessary to avoid all external building vibrations (One of the authors, RFT.

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Modeling M 1 Log Odds As before, we typically wish to model the log odds as functions of one or more explanatory variables However, this time we require M 1 equations, one for each independent log odds Each equation is equivalent to a binary logistic regression model in which the response is a conditional log odds the log odds of being in one versus being in another category of the response variable, given location in one of these two categories (Indeed, the multinomial logistic regression model can be estimated as a series of binary logistic regressions see, eg, Begg and Gray, 1984 but it is more ef cient to estimate it by maximizing a single likelihood function) Each odds is the ratio of the probabilities of being in the respective categories.

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Table 6.3 8448-kbps Digital Multiplexing Frame Structure Using Positive/ Zero/ Negative Justi cation Tributary bit rate (kbit/ s) Number of tributaries Frame Structure Frame-alignment signal (11100110) Bits from tributaries Justi cation control bits Cj 1 (see Note) Bits for service functions Bits from tributaries Justi cation control bits Cj 2 (see Note) Spare bits Bits from tributaries Justi cation control bits Cj 3 (see Note) Bits from tributaries available for negative justi cation Bits from tributaries available for positive justi cation Bits from tributaries Frame length Frame direction Bits per tributary Maximum justi cation rate per tributary

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, had the opportunity to use this facility when at Harvard) B k sy discovered that the traveling waves of the basilar membrane induced by a given tone establish a standing wave pattern that maximally displaces a given region for a given tone and different regions for different tones The pattern of displacement is more complicated than the Helmholtz theory but nonetheless provided a triumph for the place theory Actually, another kind of physiological evidence provided strong support for the place theory in the 1940s Woolsey and Walzl (1942) published an extraordinary study in which they electrically stimulated different regions of the auditory nerve bers in the cochlea (the bers are laid out along the basilar membrane) in an anesthetized cat and recorded evoked potentials in the auditory cortex The place stimulated on the cochlea determined the region of the auditory cortex activated.

Equations for all of the other M( M 1)/2 ( M 1) dependent log odds are functions of the parameters for the independent log odds, and therefore do not need to be estimated from the data Typically, we choose one category, say the Mth, of the response variable as the baseline and contrast all other categories with it (ie, the probability of being in this category forms the denominator of each odds) With 1 , 2 , , M representing the probabilities of being in category 1, category 2, , category M, of the response variable, respectively, the multinomial logistic regression model with K predictors is log.

An important practical outcome of all this work is the cochlear prosthesis developed for deaf individuals More recent studies recording the activity of single neurons in the auditory cortex have veri ed and extended these observations (eg, Hind et al, 1960) When the ear is stimulated with low-intensity pure tones (anesthetized cat), neurons in particular, narrow dorsal-ventral bands in the primary auditory cortex respond selectively to tones of different frequency The regions of the cochlea activated by pure tones are represented in an anterior-posterior series of narrow dorsal-ventral bands along the primary auditory cortex, a cochlea-topic representation Like the visual sciences, the modern eld of the hearing sciences has become an entirely separate eld with its own societies, journals, and NIH institute focusing on psychophysics and the neurobiology of the auditory system.

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