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Hi All, I have a windows application in which am displaying the PDF file in PDF viewer(Adobe Acrobat or Via WebBrowser control). I have EDIT ... A characteristic feature of medullary lesions is the occurrence, in many instances, of a crossed sensory disturbance, i.e., a loss of pain and temperature sensation on one side of the face and on the opposite side of the body. This is accounted for by involvement of the descending trigeminal tract or its nucleus and the crossed lateral spinothalamic tract on one side of the brainstem and is nearly always caused by a lateral medullary infarction (Wallenberg syndrome). In the upper medulla, pons, and midbrain, the crossed trigeminothalamic and lateral spinothalamic tracts run together; a lesion at these levels causes loss of pain and temperature sense on the opposite half of the face and body. There are no tactile paresthesias, only thermal or painful dysesthesias. In the upper brainstem, the spinothalamic tract and the medial lemniscus become con uent, so that an appropriately placed lesion causes a contralateral loss of all super cial and deep sensation. Cranial nerve palsies, cerebellar ataxia, and motor paralysis are almost invariably associated, as indicated in the discussion of strokes in this region (Chap. 34). In other words, a lesion in the brainstem at any level is unlikely to cause an isolated sensory disturbance. The overall mortality of patients with CNS tuberculosis is still signi cant (about 10 percent), infants and the elderly being at greatest risk. Among HIV-infected patients, the mortality from tuberculous meningitis is considerably higher (21 percent in the series of Berenguer et al) the result of delays in diagnosis and, more importantly, of resistance to antituberculous drugs in some patients (Snider and Roper) (see also page 1061). Early diagnosis, as one might expect, enhances the chances of survival. In patients who are treated late in the disease, when coma has supervened, the mortality rate is nearly 50 percent. Between 20 and 30 percent of survivors manifest a variety of residual neurologic sequelae, the most important of which are diminished intellectual function, psychiatric disturbances, recurrent seizures, visual and oculomotor disorders, deafness, and hemiparesis. A detailed account of these has been given by Wasz-Hockert and Donner. how to edit pdf file in asp net c# Create partial editable PDF in C# | The ASP.NET Forums
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