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endocytic compartment in B lymphocytes Nature 369:113 20 Amit, A, et al 1986 Three-dimensional structure of an antigen-antibody complex at 28 resolution Science 233:747 53 Arstila, T, et al 1999 A direct estimate of the human T cell receptor diversity Science 286:958 61 Autexier, C, and C Greider 1996 Telomerase and cancer: revisiting the telomere hypothesis Trends in Biochemical Sciences 21:387 91 Bashirullah, A, R Cooperstock, and H Lipshitz 1998 RNA localization in development Annual Review of Biochemistry 67:335 94 Bate, M, and A Martinez Arias, eds 1993 The Development of Drosophila melanogaster Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press Bhattacharyya, M, et al 1990 The wrinkled-seed character of peas described by Mendel is caused by a transposon-like insertion in a gene encoding starch-branching enzyme Cell 60:115 22 Bird, A, and A Wolffe 1999.

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rotor) is simpler than that of the PM type, because the rotor is not magnetically polarized, and therefore it is not necessary to have bipolar currents to achieve the desired rotor motion The stator of Figure 1810 is excited by DC currents supplied by a single (unipolar) voltage supply The switches shown in the gure could be controlled by a logic circuit similar to the ones described in s 13 and 14 Note that four separate coils are used Figure 1812 depicts how the rst three steps of the sequence could be achieved These are summarized in Table 184

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High-speed steel was discovered by Taylor and White in the early 1900s, and its introduction made possible a considerable increase in cutting speeds (and thus the name) Today, the same speeds are considered to be comparatively low [3] High-speed steel consists of alloying elements, mainly tungsten (about 18%) and chromium (about 4%) [1] It may also contain cobalt, vanadium or molybdenum High-speed steel is relatively inexpensive and tough, but has a limited hot hardness and can only be used for cutting temperatures up to 550 C Cast alloy tools, also known as satellites, were introduced in 1915, and consist of 38 53% cobalt, 30 33% chromium and 10 20% tungsten They have a somewhat better tool life than high-speed steels, under certain conditions However, they are fragile and weak in tension and tend to shatter when subjected to shock load [3] Therefore, cast alloy tools are only used for special applications that involve deep, continuous roughing operations at relatively high feeds and speeds for machining cast iron, malleable iron and hard bronzes

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Figure 1812 Two-phase four-pole VR motor positioning sequence Table 184 Current excitation sequence for VR step motor SA 1 1 0 0 0 0 0 1 1 SB 0 1 1 1 0 0 0 0 0 SC 0 0 0 1 1 1 0 0 0 SD 0 0 0 0 0 1 1 1 0 Rotor position 0 45 90 135 180 225 270 315 360

Methylationinduced repression Belts, braces, and chromatin Cell 99:451 54 Bischoff, J, et al 1996 An adenovirus mutant that replicates selectively in p53-de cient human tumor cells Science 274:373 76 Brown, J, et al 1993 Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1 Nature 364:33 39 Brown, M, and E Solomon 1997 Studies on inherited cancers: Outcomes and challenges of 25 years Trends in Genetics 13:202 6 Burton, D, and J Moore 1998 Why do we not have an HIV vaccine and how can we make one Nature Medicine Vaccine Supplement 4:495 98 Campos-Ortega, J, and V Hartenstein 1985 The Embryonic Development of Drosophila melanogaster Berlin: Springer-Verlag Carroll, S 1995 Homeotic genes and the evolution of arthropods and chordates Nature 376:479 85 Casares, F, and R Mann 1998 Control of antennal versus leg development in Drosophila Nature 392:723 26 Caspari, T 2000.

Determine an expression for the step angle of a VR step motor based on the number of teeth on the rotor and stator and on the number of phases

Checkpoints: How to activate p53 Current Biology 10:R315 17 Cavanee, W, and R White 1995 The genetic basis of cancer Scienti c American, March, 72 79 Cohen, L 1987 Diet and cancer Scienti c American, November, 42 48 Cold Spring Harbor Laboratory Press 1998 Mechanisms of Transcription Cold Spring Harbor Symposia on Quantitative Biology,Volume 63 New York: Cold Spring Harbor..

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