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1 Whether a given change in potassium concentration makes an excitable cell more or less excitable is not always obvious Depolarization resulting from elevated extracellular potassium may make a cell more excitable, but very strong depolarization actually decreases excitability (because of inactivation of voltagegated sodium channels), a situation called a depolarizing block In cases of very high extracellular potassium, a depolarizing block in the heart prevents propagation of the electrical signal that causes synchronized contraction

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The concept for digital wireless and cellular voice and data is rooted in the late 1930s and 40s, when commercial mobile telephony and military radio systems reached production quality At that time, the US military began experimenting with radio frequency signal encryption for data, using it to send battle plans across enemy lines and naval fleets ship to shore Lamarr and Antheil began work on the secret" CDMA signal guidance systems that would eventually find a true home in wireless phones Meanwhile, in 1934, the US Congress created the Federal Communications Commission a regulatory body designed to manage landline interstate telephone business as well as radio spectrum the ether" required to make radio networks work The Commission began parceling out spectrum parsimoniously at first, giving priority to emergency services, government agencies, utilities, and other groups deemed helpful to people After World War II the FCC began to allocate radiotelephone channels for commercial use In June 1946 in St Louis, American Telephone and Telegraph and Southwestern Bell introduced the first American commercial mobile radiotelephone, the precursor to mobile wireless today Early Mobile Radio Telephone Systems (MTS) were plagued with crosschannel interference, forcing the carrier to restrict usage and the number of channels available for voice calls (Channels are important because they relate directly to how many communications sessions can be maintained by a radio tower at any one point in time and therefore directly affect the costs of transmission) Therein began an ongoing struggle for spectrum that has lasted right up until the present day, wherein carriers depend on technology breakthroughs boosting radio signal efficiency, for example to make better use of the crowded bandwidth available

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The most difficult part of a new job, Lombardi once commented, is to analyze and understand the personality of each player

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