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In any case, if you do use the else if idiom, be sure to use an else (not an else if) as your final test, making it the default case that will execute when nothing else does.

Rickets and osteomalacia continue to be common problems in many tropical countries despite adequate exposure to sunlight A nutritional deficiency of calcium can occur in any severely malnourished patient Some degree of calcium deficiency is common in the elderly, since intestinal calcium absorption declines with age Ingestion of excessive wheat bran also causes calcium malabsorption

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Phosphatonin is a circulating peptide that inhibits sodiumdependent phosphate transport in the renal tubule; high levels of this peptide cause excessive phosphaturia, resulting in hypophosphatemia X-linked hypophosphatemic rickets is associated with high levels of phosphatonin, probably caused by familial or sporadic mutations in PHEX endopeptidase, which fails to cleave phosphatonin Oncogenic osteomalacia is caused by excessive production of phosphatonin by a wide variety of soft tissue tumors (87% benign) Such tumors may be hard to find OctreoScan has been reported to detect many of these small tumors The condition is characterized by hypophosphatemia, excessive phosphaturia, reduced or normal serum 1,25(OH)2D concentrations, and osteomalacia Excessive renal phosphate losses are also seen in proximal renal tubular acidosis and Fanconi s syndrome Some cases of hyperphosphaturia are idiopathic Other causes of hypophosphatemic osteomalacia include poor nutrition, alcoholism, or chelation of phosphate in the gut by aluminum hydroxide antacids, calcium acetate (PhosLo), or sevelamer hydrochloride (Renagel)

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Bone mineralization is inhibited by aluminum Osteomalacia may occur in patients receiving long-term renal hemodialysis with tap water dialysate or from aluminum-containing antacids used to reduce phosphate levels Osteomalacia may develop in patients being maintained on long-term total parenteral nutrition if the casein hydrolysate used for amino acids contains high levels of aluminum

Nested if statements are hard to read, hard to get right, and hard to debug. When you have a complex set of choices to make, the switch statement is a more powerful alternative. The logic of a switch statement is this: pick a matching value and act accordingly.

osteomalacia is typically asymptomatic at first Eventually, bone pain occurs, along with muscle weakness due to calcium deficiency Fractures may occur with little or no trauma

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Serum is obtained for calcium, albumin, phosphate, alkaline phosphatase, PTH, and 25[OH]D3 determinations Bone densitometry helps document the degree of osteopenia Radiographs may show diagnostic features In one series of biopsy-proved osteomalacia, alkaline phosphatase was elevated in 94% of patients; the calcium or phosphorus was low in 47% of patients; 25(OH)D3 was low in 29% of patients; pseudofractures were seen in 18% of patients; and urinary calcium was low in 18% of patients 1,25(OH)2D3 may be low even when 25(OH)D2 levels are normal Bone biopsy is not usually necessary but is diagnostic of osteomalacia if there is significant unmineralized osteoid

Skeletal alkaline phosphatase is an enzyme that is necessary to form normal bone Alkaline phosphatase cleaves pyrophosphate, an inhibitor of mineralization, thereby allowing normal mineralization of the bone matrix There are four distinct alkaline phosphatase isomers; only one is found in bone and it is also in liver and kidney and is therefore known as tissue-nonspecific alkaline phosphatase ( bone alkaline phosphatase) Hypophosphatasia, a deficiency of bone alkaline phosphatase effect, is a rare genetic cause of osteomalacia that is commonly misdiagnosed as osteoporosis The incidence in the United States is about 1 in 100,000 live births; about 1 in 300 adults is a carrier Many different mutations in the gene (designated ALPL) encoding bone alkaline phosphatase have been described, and transmission can be either autosomal recessive or autosomal dominant The phenotypic presentation of hypophosphatasia is extremely variable At its worst extreme, it can present as a stillborn without dentition or calcified bones At its mildest, hypophosphatasia can present in middle age with premature loss of teeth, foot pain (due to metatarsal stress fractures), thigh pain (due to femoral pseudofractures), or arthritis (due to chondrocalcinosis) Serum alkaline phosphatase (collected in a non-EDTA tube) is low for age in patients with hypophosphatasia To confirm the diagnosis, a 24-hour urine should be assayed for phosphoethanolamine, a substrate for tissue-nonspecific alkaline phosphatase, whose excretion is always elevated in patients with hypophosphatasia Prenatal genetic testing, by way of chorionic villus biopsy, is available for the infantile form of hypophosphatasia There is no proven therapy for hypophosphatasia, except for supportive care Teriparatide, a useful therapy for osteoporosis, has been administered to some patients with hypophosphatasia, but its long-term efficacy is unknown

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