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bral collapse may lead to spinal cord compression Osteosarcoma may develop in long-standing lesions Sarcomatous change is suggested by a marked increase in bone pain, sudden rise in alkaline phosphatase, and appearance of a new lytic lesion The increased vascularity may give rise to highoutput cardiac failure Arthritis frequently develops in joints adjacent to involved bone Extensive skull involvement may cause cranial nerve palsies from impingement of the neural foramina Ischemic neurologic events may occur as a result of a vascular steal phenomenon Involvement of the auditory region frequently causes hearing loss (mixed sensorineural and conductive) and occasionally tinnitus or vertigo
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Miacalcin, 200 IU/unit dose spray, is administered as one spray daily, alternating nostrils It is just as effective as the parenteral preparation and is associated with fewer side effects Nasal irritation may occur, as may occasional epistaxis Calcitonin has been used for many years to treat Paget s disease However, its use has declined dramatically with the introduction of more potent bisphosphonates
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Langston AL et al Management of Paget s disease of bone Rheumatology (Oxford) 2004 Aug;43(8):955 9 [PMID: 15187244] Reid IR et al Comparison of a single infusion of zoledronic acid with risedronate for Paget s disease N Engl J Med 2005 Sep 1;353(9):898 908 [PMID: 16135834] Walsh JP et al A randomized clinical trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget s disease of bone Bone 2004 Apr;34(4):747 54 [PMID: 15050907] Whyte MP Clinical practice: Paget s disease of bone N Engl J Med 2006 Aug 10;355(6):593 600 [PMID: 16899779]
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