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requires revaccination of at-risk groups every 3 5 years due to waning immunity, the protein conjugated vaccine likely will provide longer protection, although data on need for revaccination with MCV4 is not currently available MCV4 is licensed for use in individuals 11 55 years of age, and MPSV4 is licensed for ages 2 years and above Vaccination with MCV4 is routinely recommended for adolescents aged 11 12 For those who miss that vaccination, catch up is recommended at high school entry (approximately age 15) MCV4 is also recommended for certain highrisk groups, including college freshman living in dormitories (the risk to nonfreshman and freshman not living in dormitories is the same as the general population and vaccination of these groups is elective), microbiologists who are routinely exposed to N meningiditis, military recruits, persons who travel to or reside in areas in which N meningitides is hyperendemic or epidemic (see below), those with terminal complement deficiencies, and persons with anatomic or functional asplenia HIV-infected patients may be at increased risk for meningococcal disease, and vaccination should be considered elective in that group MCV4 is the preferred preparation, but if availability is an issue, MPSV4 can be substituted MCV4 is administered as a single 05-mL dose intramuscularly and MPSV4 as a single 05-mL dose subcutaneously Both can be administered with other vaccines, but at different sites and both produce an antibody response in 7 10 days Both are inactivated vaccines and can be administered to immunocompromised patients MPSV4 is safe in pregnancy, but there are no safety or efficacy data for MCV4 in pregnancy Minor reactions (fever, redness, swelling, erythema, pain) occur slightly more commonly with MCV4 Major reactions are rare The protein conjugate used in MCV4 is diphtheria toxoid, so individuals with a history of adverse reaction to that component should not receive MCV4 A potential association between Guillain-Barr syndrome and vaccination with MCV4 has been reported, but current recommendations favor continued use of MCV4, since the benefits of preventing the serious consequences of meningococcal infection outweigh the theoretical risk of Guillain-Barr syndrome.

In the previous example, the switch value was an integral constant. C# also offers the ability to switch on a string. Thus, you can rewrite Example 5-9 to switch on the string "NewLeft", as in Example 5-10.

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or protection against strains that were present before vaccination The ACIP recommends routine vaccination of females 11 12 years of age with three intramuscular doses; the second and third doses should be given 2 and 6 months after the first No changes in cervical cancer screening have been recommended in vaccinated individuals The vaccine has not been evaluated in males or for pregnant women and is not recommended for these groups The vaccine is well tolerated with most reactions being mild to moderate local ones (pain, erythema, swelling) Systemic reactions, mainly fever, was seen in 4% of recipients Absolute contraindications include a history of hypersensitivity to yeast or to any vaccine component Unanswered questions include the need for booster doses to prevent the development of cervical cancer and whether males should also be vaccinated

Individuals traveling to other countries frequently require immunizations in addition to those listed above and may benefit from chemoprophylaxis against various diseases These are listed in Health Information for International Travel, published by the CDC An updated version is published yearly and is available from the Superintendent of Documents, United States Government Printing Office, Washington, DC 20402, or on the Internet: http://wwwcdcgov/nip Various vaccines can be given simultaneously at different sites Some, such as cholera, plague, and typhoid vaccine, cause significant discomfort and are best given at different times In general, live attenuated vaccines (measles, mumps, rubella, yellow fever, and oral typhoid vaccine) should not be given to immunosuppressed individuals or household members of immunosuppressed people or to pregnant women Immunoglobulin should not be given for 3 months before or at least 2 weeks after live virus vaccines, because it may attenuate the antibody response Chemoprophylaxis of malaria is discussed in 35

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