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Typhoid vaccination is recommended for travelers to developing countries (especially the Indian subcontinent, Asia, Africa, Central and South America, and the Caribbean) who will have prolonged exposure to contaminated food and water Two preparations of approximately equal efficacy (50 75% effective) are available in the United States: (1) an oral live-attenuated Ty21a vaccine supplied as enteric-coated capsules, and (2) a Vi capsular polysaccharide (Vi CPS) vaccine for parenteral use The Ty21a vaccine is given as one capsule every other day for four doses The capsules must be refrigerated and taken with cool liquids (37 C or less) at least 1 hour before meals All four doses must be taken for maximum protection and should be completed 1 week before travel It is not recommended for infants or children younger than 6 years Adverse effects are minimal and consist primarily of gastrointestinal upset The Vi CPS vaccine is given as a single intramuscular injection at least 2 weeks prior to travel It is not recommended for infants younger than 2 years Adverse effects consist mainly of local irritation at the site of injection, but fever and headache occur If continued or repeated exposures are anticipated, boosters are recommended every 2 years for the Vi CPS and every 5 years for the Ty21a The live attenuated vaccine should not be used in immunosuppressed patients, including those with HIV infection

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If travel is contemplated to an area where meningococcal meningitis is epidemic (Nepal, sub-Saharan Africa, the meningitis belt from Senegal in the west to Ethiopia in the east, northern India) or highly endemic, vaccination with MCV4 is indicated for those 11 55 years of age, otherwise MPSV should be used (Saudi Arabia requires immunization for pilgrims to Mecca)

Increases catecholamine excretion May cause confounding peaks on HPLC chromatograms 3 Decreases catecholamine excretion

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in patients with azotemia or hypergastrinemia, and in those treated with corticosteroids or proton pump inhibitors Serum may also be assayed for neuron-specific enolase; high levels implicate a malignant pheochromocytoma, while normal levels are nonspecific Pharmacologic provocative and suppressive tests that evaluate the rise or fall in blood pressure are usually not required or recommended Genetic testing should ideally be performed on all patients with pheochromocytoma or paraganglioma Testing for VHL, ret protooncogene, and SDHB/SDHD mutations is advisable Family members may then be screened for the specific gene mutation

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Tachycardia, tremor, palpitation, and hypermetabolism may give rise to confusion with thyrotoxicosis Pheochromocytoma may also be misdiagnosed as essential hypertension, myocarditis, glomerulonephritis or other renal lesions, toxemia of pregnancy, eclampsia, and psychoneurosis (anxiety attack) It can sometimes be mistaken for an acute abdomen Other conditions that have manifestations similar to those of pheochromocytoma include acute intermittent porphyria,

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1 CT and MRI scanning Imaging should not usually replace biochemical testing, since incidental adrenal adenomas are common (2 4% of scans) and can be misleading When a pheochromocytoma is suspected because of biochemical testing or a genetic condition predisposing to pheochromocytoma, a CT scan of the abdomen is performed, with