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may slow the pace of weight loss, as does treating the underlying opportunistic infection Food supplementation with highcalorie drinks may enable patients with not much appetite to maintain their intake Selected patients with otherwise good functional status and weight loss due to unrelenting nausea, vomiting, or diarrhea may benefit from total parenteral nutrition (TPN) It should be noted, however, that TPN is more likely to increase fat stores than to reverse the muscle wasting process Two pharmacologic approaches for increasing appetite and weight gain are the progestational agent megestrol acetate (80 mg four times a day) and the antiemetic agent dronabinol (25 5 mg three times a day) Side effects from megestrol acetate are rare, but thromboembolic phenomena, edema, nausea, vomiting, and rash have been reported Euphoria, dizziness, paranoia, and somnolence and even nausea and vomiting have been reported in 3 10% of patients using dronabinol Dronabinol contains only one of the active ingredients in smoked marijuana, and many patients report better relief of nausea and improvement of appetite with smoking marijuana Several states allow physicians to recommend the use of smoked marijuana to their patients However, it is still illegal in the United States to sell marijuana Thus, a physician s recommendation may at best decrease the chance that patients will be prosecuted for use of marijuana Unfortunately, neither megestrol acetate nor dronabinol increases lean body mass Two regimens that have resulted in increases in lean body mass are growth hormone and anabolic steroids Growth hormone at a dose of 01 mg/kg/d (up to 6 mg) subcutaneously for 12 weeks has resulted in modest increases in lean body mass Treatment with growth hormone can cost as much as $10,000 per month Anabolic steroids also increase lean body mass among HIV-infected patients They seem to work best for patients who are able to do weight training The most commonly used regimens are testosterone enanthate or testosterone cypionate (100 200 mg intramuscularly every 2 4 weeks) Testosterone transdermal system (apply 5 mg system each evening) and testosterone gel (1%; apply a 5-g packet [50 mg testosterone] to clean, dry skin daily) are also available The anabolic steroid oxandrolone (20 mg orally in two divided doses) has also been found to increase lean body mass Nausea leading to weight loss is sometimes due to esophageal candidiasis Patients with oral candidiasis and nausea should be empirically treated with an oral antifungal agent Patients with weight loss due to nausea of unclear origin may benefit from use of antiemetics prior to meals (prochlorperazine, 10 mg three times daily; metoclopramide, 10 mg three times daily; or ondansetron, 8 mg three times daily) Dronabinol (5 mg three times daily) can also be used to increase appetite Depression and adrenal insufficiency are two potentially treatable causes of weight loss 2 Pulmonary disease a PNEUMOCYSTIS pneumonia (See also discussions in 36) Pneumocystis jiroveci pneumonia is the most common opportunistic infection associated with AIDS Pneumocystis pneumonia may be difficult to diagnose because the symptoms fever, cough, and shortness of breath are nonspe-.

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