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(podophyllin) in compound tincture of benzoin Pregnant patients should not be so treated The purified active component of the resin, podofilox, is available for use at home twice daily 3 consecutive days a week for cycles of 4 6 weeks It is less irritating and more effective than podophyllum resin After a single 4-week cycle, 45% of patients were wartfree; but of these, 60% relapsed at 6 weeks Thus, multiple cycles of treatment are often necessary 4 Imiquimod A 5% cream of this local interferon inducer has moderate activity in clearing external genital warts Seventy-seven percent of women and 40% of men with external genital warts had complete clearing of their lesions Treatment is once daily on 3 alternate days per week Response may be slow, with patients who eventually cleared having responses at 8 weeks (44%) or 12 weeks (69%) Once cleared, about 13% had recurrences in the short term There is less pregnancy risk than with podophyllum resin (category B versus category X with podophyllin) It is more expensive than podophyllotoxin, but given the high rate of response in women and its safety, it appears to be the patient-administered treatment of choice in women In men, the more rapid response, lower cost, and similar efficacy make podophyllotoxin the initial treatment of choice, with imiquimod used for recurrences or refractory cases Imiquimod has no demonstrated efficacy for and should not be used to treat plantar or common warts 5 Operative removal Plantar warts may be removed by blunt dissection Trichloroacetic acid or Monsel s solution on a tightly wound cotton-tipped applicator may be painted on the wound, or light electrocautery may be used For genital warts, snip biopsy (scissors) removal followed by light electrocautery is more effective than cryotherapy, especially for patients with pedunculated or large lesions 6 Laser therapy The CO2 laser can be effective for treating recurrent warts, periungual warts, plantar warts, and condylomata acuminata It leaves open wounds that must fill in with granulation tissue over 4 6 weeks and is best reserved for warts resistant to all other modalities Lasers with emissions of 585, 595, or 532 nm may also be used every 3 4 weeks to gradually ablate common or plantar warts This is no more effective than cryotherapy in controlled trials For genital warts, it has not been shown that laser therapy is more effective than electrosurgical removal 7 Other agents Bleomycin diluted to 1 unit/mL may be injected into warts It has been shown to have a high cure rate for plantar and common warts It should not be used on digital warts because of the potential complications of Raynaud s phenomenon, nail loss, and terminal digital necrosis.
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