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f Progressive multifocal leukoencephalopathy (PML) PML is a viral infection of the white matter of the brain seen in patients with very advanced HIV infection It typically results in focal neurologic deficits such as aphasia, hemiparesis, and cortical blindness Imaging studies are strongly suggestive of the diagnosis if they show nonenhancing white matter lesions without mass effect Extensive lesions may be difficult to differentiate from the changes caused by HIV Several patients have stabilized or improved after the institution of combination antiretroviral therapy or cidofovir 4 Peripheral nervous system Peripheral nervous system syndromes include inflammatory polyneuropathies, sensory neuropathies, and mononeuropathies An inflammatory demyelinating polyneuropathy similar to Guillain-Barr syndrome occurs in HIV-infected patients, usually prior to frank immunodeficiency The syndrome in many cases improves with plasmapheresis, supporting an autoimmune basis of the disease CMV can cause an ascending polyradiculopathy characterized by lower extremity weakness and a neutrophilic pleocytosis on spinal fluid analysis with a negative bacterial culture Transverse myelitis can be seen with herpes zoster or CMV Peripheral neuropathy is common among HIV-infected persons Patients typically complain of numbness, tingling, and pain in the lower extremities Symptoms are disproportionate to findings on gross sensory and motor evaluation Beyond HIV infection itself, the most common cause is prior antiretroviral therapy with stavudine or didanosine Patients who report these symptoms should be switched to an alternative agent if possible Caution should be used when administering these agents to patients with a history of peripheral neuropathy Unfortunately, drug-induced neuropathy is not always reversed when the offending agent is discontinued Patients with advanced disease may also develop peripheral neuropathy even if they have never taken antiretroviral therapy Evaluation should rule out other causes of sensory neuropathy such as alcoholism, thyroid disease, vitamin B12 deficiency, and syphilis Treatment of peripheral neuropathy is aimed at symptomatic relief Patients should be initially treated with gabapentin (start at 300 mg at bedtime and increase to 300 900 mg orally three times a day) Although many clinicians initiate a trial of amitriptyline (10 25 mg orally at bedtime), responses to this agent are uncommon 5 Rheumatologic manifestations Arthritis, involving single or multiple joints, with or without effusion, has been commonly noted in HIV-infected patients Involvement of large joints is most common Although the cause of HIVrelated arthritis is unknown, most patients will respond to nonsteroidal anti-inflammatory drugs Patients with a sizable effusion, especially if the joint is warm or erythematous, should have the joint tapped, followed by culture of the fluid to rule out suppurative arthritis as well as fungal and mycobacterial disease Several rheumatologic syndromes, including reactive arthritis (Reiter s syndrome), psoriatic arthritis, sicca syndrome, and systemic lupus erythematosus, have been reported in HIV-infected patients (see 20) However,.
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Because of the problems created by the goto statement, it is rarely used in C# outside of switch statements, but in the interest of completeness, here s how you create goto loops: 1. Create a label. 2. goto that label. The label is an identifier followed by a colon. You place the label in your code, and then you use the goto keyword to jump to that label. The goto command is typically tied to an if statement, as illustrated in Example 5-11.
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