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PDF Generation in Azure Functions V2 - OdeToCode
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Polyclonal antineuronal antibodies (IgG) directed against a 35 40 kD protein or complex of proteins, the so-called Hu antigen, are found in the sera or cerebral spinal uid (CSF) in the majority of patients with paraneoplastic PEM/SN3,5 13,32 The presence of anti-Hu antibodies in the serum correlates with SN,11 while antibodies in the CSF are associated with the development of PEM12 In a study of 49 patients with paraneoplastic sensory neuropathy, anti-Hu antibodies were present in the serum of 40/49 patients6 In 77 patients with idiopathic sensory neuropathy, anti-Hu antibodies were found in only one patient6 Thus, the sensitivity and speci city of the anti-Hu antibodies are high However, 12% of patients with paraneoplastic SN did not have anti-Hu antibodies Therefore, all patients suspected of having PEM/SN should undergo periodic screening for an underlying malignancy, regardless of their anti-Hu antibody status CSF may be normal or may demonstrate mild lymphocytic pleocytosis and elevated protein3,5,12,32 Oligoclonal bands and increased CSF IgG synthesis and inTABLE 17 2 CAUSES OF SENSORY NEUROPATHY/GANGLIONOPATHY

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Azure and the Google Cloud Vision OCR do not take PDF files as input. The only OCR API that take PDFs as input are the free OCR API and ...

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Azure Apps (former WebSites) operate in restricted (partial-trust) environment and wkhtmltopdf.exe (that is internally used by NReco PdfGenerator wrapper) ...

Paraneoplastic (anti-Hu syndrome) Sjogren syndrome Human immunode ciency virus infection Toxic agents (eg, chemotherapy, pyridoxine, and antinucleosides) Guillain-Barre syndrome variant Idiopathic sensory neuronopathy

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Modi ed with permission from Amato AA, Anderson MP A 51 year old woman with lung cancer and neuropsychiatric abnormalities (Case 38 2001) N Engl J Med 2001;354:1758 1765

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PEM/SN is probably the result of antigenic similarity between proteins expressed in the tumor cells and the neuron cells (eg, Hu antigens), leading to an immune response directed against both tumor and neuronal cells3,5,20,21,32,34 The Hu antigen is a family of four similar RNA-binding proteins (HuD, HuC/ple21, Hel-N1, and Hel-N2) The Hu antigen is expressed in the nuclei and to a lesser extent in the cytoplasm of neurons and SCLC cells10 The function of this group of proteins is

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Figure 17 1 (A) Dorsal-root ganglia of the cervical cord, showing marked parenchymal and perivascular in ammation, loss of ganglion cells, and brosis (Hematoxylin and Eosin, 100) (B) Section of cervical spinal cord showing marked pallor of the dorsal columns (arrows) (Luxol Fast Blue Hematoxylin and Eosin, 5) (With permission from Amato AA, Anderson MP A 51 year old woman with lung cancer and neuropsychiatric abnormalities (Case 38 2001) N Engl J Med 2001;354:1758 1765, Figs 5 and 7, p 1763, 1764)

FIGURE 2-9

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not known, but these are thought to be crucial in the development and maintenance of the nervous system21 The role of the anti-Hu antibodies in the development of PEM/NS is also unclear The antibodies appear to bind to CNS and PNS neurons affected in the syndrome13,16 19 There is a correlation of high anti-Hu titers in the CSF

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Figure 17 2 Amygdalar complex with a perivascular lymphocytic in ltrate and microglial nodules (Hematoxylin and Eosin, 100) (With permission from Amato AA, Anderson MP A 51 year old woman with lung cancer and neuropsychiatric abnormalities (Case 38 2001) N Engl J Med 2001;354:1758 1765, Fig 6, p 1764)

and the development of PEM,12 and the serum titer with the occurrence of SN11 However, the anti-Hu antibodies have not been proved to be pathogenic Passive transfer of autoantibodies from patients with PEM/SN and immunization with puri ed HuD protein have failed to reproduce the disease in animal studies24 Further, the anti-Hu antibodies exhibit only weak complement activation19,25 More recently, the focus has shifted to the role of the cellular immune response in PEM/SN26 The perivascular in ltrate in tumors and the nervous system consists mainly of CD4+ cells, B cells, and macrophages, while CD4+ cells, cytotoxic T cells, and microglia-like cells predominate in the tissue immediately surrounding neurons19,26 T-cell receptor studies on the in ammatory in ltrate in the nervous system and within the tumors of anti-Hu-positive PEM/SN patients reveal a limited V repertoire and clonal expansion suggestive of an antigen-driven cytotoxic T-cell response27 Studies have demonstrated an increase of CD45RO+CD4+ memory helper T cells in the peripheral blood of patients with anti-PEM/SN26 Antigen-speci c proliferation of these T cells occurred following in vitro stimulation of cultured lymphocytes with puri ed HuD antigen In addition, the cells secreted interferon- , suggesting that these lymphocytes were primarily of the Th1 helper subtype The authors speculated that neoplastic cells express the Hu antigen previously produced by fetal cells but lie sequestered in adult neurons Autoreactive CD4+ T cells that escaped thymic deletion may become activated by the tumor expressing the Hu antigen These cells, in turn, activate CD4+ Th1 T cells that migrate to the tumor and into the nervous system as well, inducing a direct cytotoxic effect on tumor cells and on neurons

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generate a PDF in an Azure App Service - MSDN - Microsoft
I'm currently trying to use a PDF generator in my project but it doesn't work in an Azure Web app. I am using something called SelectPDF to ...

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