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Instead the incorrect number should be neatly lined through once, the new number inserted next to the old number, initialed to show who made the change, and a notation made as to why the correction was made This should be done even if there is only one person in the payroll department Noting why a correction is made is a critical step This allows anyone, including the payroll staff member who made the correction, to clearly see why the change was made if it should ever come up weeks, months, or years later, which can happen If the employee is requesting a bene t leave and does not have suf cient leave, the same system is used as described above to correct the time record to re ect the new hours to be paid.
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For the purposes of this discussion, pharmacologic research is very broadly de ned and considered to include three areas The rst area is drug discovery or development The second area is often described as pharmacogenetics This is the study of differences in ef cacy or toxicity of drugs and treatment protocols in different individuals and is increasingly focusing on understanding the genetic basis and biological mechanisms for hypo- and hyperresponse to pharmacologic agents The third area, disease prevention, is not often included in discussions of pharmacogenetics and pharmacogenomics, but disease prevention is the ultimate treatment As with individual variation in response to pharmacologic agents or drugs, there is also variation among individuals in the risk of disease following an exposure Genetic susceptibility to disease is mechanistically closely coupled to pharmacogenetics and often involves the same sets of genes.
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(d) Auditing Procedures after Processing After processing the time records it is a standard custom and certainly a best practice to audit (more commonly referred to as edit ) the time records that have been input A general edit is also done on other remaining input information during this time This edit ensures that what should have gone in, did go in nothing more and certainly nothing less Edit reports are critical to an ef cient time record process These edit reports are generally built right into the payroll system and should at least include:.
Brown, A L, Palincsar, A S, & Armbruster, B B (1994) Instructing comprehensionfostering activities in interactive learning situations In R B Ruddell, M R Ruddell, & H Singer (Eds), Theoretical models and processes of reading (4th ed, pp 757 787) Newark, DE: International Reading Association Brown, J K (1988) Valproate toxicity Developmental Medicine and Child Neurology, 80, 115 125 Brown, M B (1999) The mucopolysaccharidoses In G W Goldstein & C R Reynolds (Eds), Handbook of neurodevelopmental and genetic disorders in children (pp 317 336) New York: Guilford Brown, M B, & Trivette, P S (1998) Mucopolysaccharide disorders (Hurler, Scheie, Hurler- Scheie, Hunter, Morquio, and San lippo syndromes) In L Phelps (Ed), Health-related disorders in children and adolescents: A guidebook for understanding and educating (pp 442 452) Washington, DC: American Psychological Association Brown, R T, Amler, R W, Freeman, W S.
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The major difference between the two areas is the characteristics of the exposure Drug exposures are well characterized and quanti ed, whereas exposures to pollutants are usually neither well characterized nor quanti ed Studies of disease susceptibility have been included under such rubrics as environmental genomics and toxicogenomics rather than being considered a component of pharmacogenomics Pharmacogenomics can also be described as the application of highthroughput technology to generate data on a global scale at the interface of genetics, disease, toxicology, and pharmacology An even more encompassing view would describe pharmacogenomics as an effort to (1) emulate the strategies of the HGP and (2) utilize the fruits of the HGP to reduce the incidence of disease and improve the practice of medicine, while reducing health care costs As with the HGP, pharmacogenomics is generally a new approach to research and speci cally data generation rather than new science.
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